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KMID : 0358920090360040531
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Journal of the Korean Academy of Pedodontics
2009 Volume.36 No. 4 p.531 ~ p.538
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INHIBITION OF GLUCAN SYNTHESIS RELATED GENE EXPRESSION OF STREPTOCOCCUS MUTANS BY XYLITOL TREATMENT
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Kim Ji-Hye
Lee Young-Eun
Ahn Sang-Hun
Choi Youn-Hee
Nam Soon-Hyeun
Song Keun-Bae
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Abstract
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Xylitol has the ability to reduce the adherence of Streptococcus mutans(S. mutans), which can make it easier to remove plaque, decrease acid production and inhibit dental caries. There are few reports on the effects of xylitol on the expression of the virulence related genes in S. mutans. This study examined the inhibitory effect of chewing gum containing xylitol on glucan synthesis related gene expression of S. mutans. Participants were voluntarily recruited for a women’s oral health prevention program, classified into two groups(a control and a xylitol group), and then followed for 2 years. Twenty salivary samples were randomly selected from each group. Colony count and real-time reverse transcription polymerase chain reaction were used to analyze the characteristics of S. mutans. The follwing results were obtained: The S. mutans counts decreased steadily in the xylitol group over the study period(p<0.05). The expression of the virulence related genes(gtfB, gtfC and gtfD) was significantly lower in the xylitol group than in the control groups(p<0.05). In conclusion, these results suggest that chewing xylitol gum for a long period of time may reduce the expression of the genes associated with S. mutans virulence, which can result in a decrease growth of S. mutans colonies as a result.
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KEYWORD
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Glucan synthesis related gene, Streptococcus mutans, Xylitol
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